| 000 | 05698cam a2200901Ia 4500 | ||
|---|---|---|---|
| 001 | ocn746321023 | ||
| 003 | OCoLC | ||
| 005 | 20171224113700.0 | ||
| 006 | m o d | ||
| 007 | cr cn||||||||| | ||
| 008 | 110811s2011 njua ob 001 0 eng d | ||
| 010 | _z 2010043286 | ||
| 040 |
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| 020 |
_a9781118001042 _q(electronic bk.) |
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| 020 |
_a1118001044 _q(electronic bk.) |
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| 020 |
_a9781118001035 _q(electronic bk.) |
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| 020 |
_a1118001036 _q(electronic bk.) |
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| 020 |
_a9781118008980 _q(electronic bk.) |
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| 020 |
_a1118008987 _q(electronic bk.) |
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| 020 |
_z9780470449820 _q(cloth) |
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_a(OCoLC)746321023 _z(OCoLC)748534058 _z(OCoLC)756496448 _z(OCoLC)759159342 _z(OCoLC)811493622 _z(OCoLC)832589834 _z(OCoLC)860516526 _z(OCoLC)961549081 _z(OCoLC)962639971 _z(OCoLC)966261537 |
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| 037 |
_a10.1002/9781118001042 _bWiley InterScience _nhttp://www3.interscience.wiley.com |
||
| 050 | 4 |
_aRA1224.3 _b.B68 2011eb |
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| 060 | 4 | _aQV 38 | |
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_a616/.042 _222 |
| 049 | _aMAIN | ||
| 245 | 0 | 0 |
_aApplications of toxicogenomics in safety evaluation and risk assessment / _cedited by Darrell R. Boverhof, B. Bhaskar Gollapudi. |
| 260 |
_aHoboken, N.J. : _bJohn Wiley & Sons, _c©2011. |
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| 300 |
_a1 online resource (xiii, 377 pages) : _billustrations |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_adata file _2rda |
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| 380 | _aBibliography | ||
| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | _aToxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan -- -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach. | |
| 520 | _a"This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm"--Provided by publisher. | ||
| 588 | 0 | _aPrint version record. | |
| 650 | 0 | _aGenetic toxicology. | |
| 650 | 0 | _aToxicity testing. | |
| 650 | 0 | _aHealth risk assessment. | |
| 650 | 7 |
_aHEALTH & FITNESS _xDiseases _xGenetic. _2bisacsh |
|
| 650 | 7 |
_aMEDICAL _xGenetics. _2bisacsh |
|
| 650 | 7 |
_aGenetic toxicology. _2fast _0(OCoLC)fst00940097 |
|
| 650 | 7 |
_aHealth risk assessment. _2fast _0(OCoLC)fst00953250 |
|
| 650 | 7 |
_aToxicity testing. _2fast _0(OCoLC)fst01153336 |
|
| 650 | 2 | _aToxicogenetics. | |
| 650 | 2 | _aRisk Assessment. | |
| 655 | 4 | _aElectronic books. | |
| 655 | 4 | _aElectronic resource. | |
| 655 | 7 |
_aElectronic books. _2local |
|
| 700 | 1 | _aBoverhof, Darrell R. | |
| 700 | 1 | _aGollapudi, B. Bhaskar. | |
| 776 | 0 | 8 |
_iPrint version: _tApplications of toxicogenomics in safety evaluation and risk assessment. _dHoboken, N.J. : John Wiley & Sons, ©2011 _z9780470449820 _w(DLC) 2010043286 _w(OCoLC)671385938 |
| 856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118001042 _zWiley Online Library |
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