Perinatal stem cells [electronic resource] / edited by Kyle J. Cetrulo [and others].

Includes bibliographical references and index.

Print version record and CIP data provided by publisher.

Perinatal Stem Cells, 2nd Edition builds on the first edition to provide an updated tutorial on perinatal stem cells, including stem cells harvested from the amniotic fluid, placenta, maternal blood supply, umbilical cord and Wharton's Jelly. As in the first edition, coverage includes the underlying biology of each of the sources of pregnancy related stem cells, cell culture, and potential therapeutic uses, as well as insights on the impact of these stem cells from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers. Normally discard.

TITLE PAGE; COPYRIGHT PAGE; CONTRIBUTORS; INTRODUCTION; INDUSTRY REVIEW; 1 AMNIOTIC FLUID STEM CELLS; INTRODUCTION; DEVELOPMENT OF GESTATIONAL STEM CELLS; ISOLATION AND CHARACTERIZATION OF AMNIOTIC FLUID STEM CELLS; MULTIPOTENCY OF AMNIOTIC FLUID STEM CELLS; CLINICAL APPLICATION OF AMNIOTIC FLUID STEM CELLS; CONCLUSION; 2 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE; INTRODUCTION; HEMATOPOIETIC STEM CELL TRANSPLANTS: ADULT DONOR COLLECTION; HEMATOPOIETIC STEM CELL TRANSPLANTS: HLA MATCHING; COLLECTION AND PROCESSING OF CORD BLOOD UNITS

HEMATOPOIETIC STEM CELL TRANSPLANTS: RECIPIENT ISSUESBONE MARROW VERSUS SINGLE CORD BLOOD: PEDIATRIC; BONE MARROW VERSUS CORD BLOOD: ADULTS; CORD BLOOD TRANSPLANT: ADVANTAGES AND DISADVANTAGES; DOUBLE CORD BLOOD TRANSPLANTS: ABLATIVE REGIMENS; DOUBLE CORD BLOOD TRANSPLANT: NON-MYELOABLATIVE REGIMENS; ARE TWO CORDS BETTER THAN ONE?; CHIMERISM; PREDICTING THE WINNER; OTHER EXPERIMENTAL STRATEGIES; SUMMARY; 3 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA; INTRODUCTION; THE HEMATOPOIETIC SYSTEM; HISTORICAL PERSPECTIVE ON PLACENTAL HEMATOPOIESIS

THE DEVELOPMENT AND STRUCTURE OF THE MOUSE PLACENTAHEMATOPOIETIC ACTIVITY IN THE MOUSE PLACENTA; IDENTIFICATION OF PLACENTAL HSCs; THE ORIGIN AND LOCALIZATION OF PLACENTAL HSCs; HEMATOPOIETIC ACTIVITY IN THE HUMAN PLACENTA; HEMATOPOIETIC MICROENVIRONMENT IN THE PLACENTA; CONCLUSIONS AND PERSPECTIVES; 4 PERINATAL MESENCHYMAL STEM CELL BANKING FOR UMBILICAL CORD BLOOD TRANSPLANTATION AND REGENERATIVE MEDICINE; INTRODUCTION; HEMATOPOIESIS; HEMATOPOIETIC TRANSPLANTATIONS; UMBILICAL CORD: SOURCE OF PERINATAL HSCs AND MSCs; HEMATOPOIETIC TRANSPLANTATIONS OF UMBILICAL CORD BLOOD

STRATEGIES TO OVERCOME THE TRANSPLANT-RELATED LIMITATIONS OF UMBILICAL CORD BLOODUMBILICAL CORD TISSUE MSC BANKING; 5 MAKING ORGAN AND STEM CELL TRANSPLANTATION SAFER: THE ROLE OF MESENCHYMAL STEM CELLS; INTRODUCTION; MSC TO PREVENT REJECTION AFTER SOLID ORGAN TRANSPLANTATION; MSC IN THE TREATMENT OF GRAFT-VERSUS-HOST DISEASE; MSC TO SUPPORT HEMATOPOIETIC RECOVERY OF STEM CELLS AFTER STEM CELL TRANSPLANTATION; 6 WHARTON'S JELLY MESENCHYMAL STEM CELLS AND IMMUNE MODULATION: REGENERATIVE MEDICINE MEETS TISSUE REPAIR; INTRODUCTION

EXPRESSION OF RELEVANT IMMUNOMODULATORY MOLECULES IN VITRO BY MSCsTOLERANCE INDUCTION BY MSCs: REDISCOVERING THE EMBRYO IMMUNE EVASION MECHANISMS; IMMUNE MODULATION IN VIVO: CONTRASTING DATA ON THE IMMUNE PRIVILEGE OF MSCs; WJ-MSC IN IN VIVO MODELS: ENHANCING THE IMMUNOMODULATORY FEATURES OF ADULT MSC POPULATIONS; CONCLUSIONS AND FUTURE PERSPECTIVES; 7 IMMUNOGENICITY VERSUS IMMUNOMODULATION OF PERINATAL STEM CELLS; INTRODUCTION; MECHANISMS OF IMMUNOMODULATION BY UMBILICAL CORD- AND BONE MARROW-DERIVED MSCs; INNATE IMMUNE SYSTEM; ADAPTIVE IMMUNE SYSTEM