Protein and peptide mass spectrometry in drug discovery / edited by Michael L. Gross, Guodong Chen, Birendra N. Pramanik.

Includes bibliographical references and index.

Ionization methods in protein mass spectrometry / Ismael Cotte-Rodriguez [and others] -- Ion activation and mass analysis in protein mass spectrometry / Cheng Lin and Peter O'Connor -- Target proteins : bottom-up and top-down proteomics / Michael Boyne and Ron Bose -- Quantitative proteomics by mass spectrometry / Jacob Galan, Anton Iliuk and W. Andy Tao -- Comparative proteomics by direct tissue analysis using imaging mass spectrometry / Michelle L. Reyzer and Richard M. Caprioli -- Peptide and protein analysis using ion mobility-mass spectrometry / Jeffrey R. Enders [and others] -- Chemical footprinting for determining protein properties and interactions / Sandra A. Kerfoot and Michael L. Gross -- Microwave technology to accelerate protein analysis / Urooj A. Mirza, Birendra N. Pramanik and Ajay K. Bose -- Bioinformatics and database searching / Surendra Dasari and David L. Tabb -- Mass spectrometry-based screening and characterization of protein-ligand complexes in drug discovery / Christine L. Andrews [and others] -- Utilization of mass spectrometry for the structural characterization of biopharmaceutical protein products / Amareth Lim and Catherine A. Srebalus Barnes -- Post-translationally modified proteins : glycosylation, phosphorylation, and disulfide bond formation / Anthony Tsarbopoulos and Fotini N. Bazoti -- Mass spectrometry of antigenic peptides / Henry Rohrs -- Neuropeptidomics / Jonathan V. Sweedler, Fang Xie and Adriana Bora -- Mass spectrometry for the study of peptide drug metabolism / Patrick J. Rudewicz.

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for th.

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